Paper details

Title:

Identification of Anti-Lung Cancer Extract from Chlorella Vulgaris C-C by Antioxidant Property Using Supercritical Carbon Dioxide Extraction

Author(s):

Chen, H.-A., Chen, T.-W., Wang, H.-M., Pan, J.-L.

Document(s):

Abstract:

In this study, supercritical carbon dioxide extraction (SC­CO2) technology was developed to extract the active components (such as antioxidants) from a novel microalga, Chlorella vulgaris C­C, due to its superior advantages over conventional solvent or ultrasonic extraction methods. Using SC­CO2 and ultrasonic extractions, the polyphenol contents of C. vulgaris C­C were 13.40 and 0.46 (mg gallic acid/g lyophilized extract), respectively. The flavonoid content obtained from SC­CO2 (3.18 mg quercetin/g lyophilized extract) was also significantly higher than from ultrasonic extraction (0.86 mg quercetin/g lyophilized extract). Investigation of C. vulgaris C­C extract from SC­CO2 indicates strong antioxidant activities in radical scavenging, ferric reducing power and metal chelating abilities. In cell proliferation assay, the extract of C. vulgaris C­C inhibits human lung cancer H1299 cells in a dose­dependent manner. In addition, the treatment with extracts of C. vulgaris C­C effectively reduced the migration of tumor cells, suggesting the potential of using the C. vulgaris C­C extract to inhibit lung cancer metastasis.

Keywords:

biomass, bioproducts, microalgae, reduction carbon dioxide

Topic:

Biomass Chemistry

Subtopic:

Emerging technologies for biomass use

Event:

18th European Biomass Conference and Exhibition

Session:

OB7.6

Pages:

1465 - 1471

ISBN-13:

978-88-89407-56-1

ISBN-10:

88-89407-56-5

Paper DOI:

10.5071/18thEUBCE2010-OB7.6

Price:

FREE